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    The University of South Carolina
    Department of Chemical Engineering
    2C02, Swearingen Engineering Center
    301 South Main Street
    Columbia, SC 29208

    Ph 803.777.4181
    Fax 803.777.8265

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    Columbia, SC

Esmaiel Jabbari

Professor


Bridging the Gap Between Synthetic Polymers and Biological Macromolecules

Professor Jabbari’s group research interests are in the area of tissue engineering. Tissue engineering is the science and engineering of cells to grow, regenerate and maintain living tissues and organs. It involves the creation of novel biomaterials and fabrication of constructs for cell immobilization or targeted delivery of signaling factors. Continued progress in the area of tissue engineering depends on our ability to develop novel technologies to fabricate patterned structures with well-defined pore micro-architecture that degrade concurrent with tissue regeneration and remodeling. These structures seeded with multi-potent stem cells allow us to study the effect of pore micro-architecture, cell signaling factors distribution and gradient on cell function and extracellular matrix formation. Such understanding is critical for the application of tissue engineering in regenerative medicine to treat a variety of diseases including musculoskeletal, cardiovascular, and neural disorders. Techniques under development in our laboratory include self-assembling biomaterials and microprinting for fabrication of patterned well-defined porous structures for cell immobilization.

Education
  • Ph. D. Chemical Engineering, Purdue University (1993)
  • M. S. Chemistry, Virginia Polytechnic Institute and State University (1989)
  • M. S. Chemical Engineering, Virginia Polytechnic Institute and State University (1986)
  • B. S. Chemical Engineering, Virginia Polytechnic Institute and State University (1982)
Selected Publications
  • "Modeling the Viscoelastic Response of Suspension of Particles in Polymer Solution: The Effect of Polymer-Particle Interactions", A.S. Sarvestani and E. Jabbari, Macromolecular Theory and Simulations, in Press (2007).
  • "A model for the viscoelastic behavior of nanofilled hydrogel composites under oscillatory shear loading", A.S. Sarvestani and E. Jabbari, Polymer Composites, in Press (2007).
  • "Material Properties and Cytocompatibility of Injectable MMP Degradable Poly(lactide ethylene oxide fumarate) Hydrogel as a Carrier for Marrow Stromal Cells," X. He and E. Jabbari, Biomacromolecules, online (PMID:17295540) (2007).
  • "The Effect of osteonectin-derived peptide on the viscoelasticity of hydrogel/apatite nanocomposite scaffolds," A.S. Sarvestani, X. He, and E. Jabbari, Biopolymers, 85-4, 370-378 (2007).
  • "Viscoelastic characterization and modeling of gelation kinetics of injectable in situ crosslinkable poly(lactide-ethylene oxide-fumarate) hydrogels," A.S. Sarvestani, X. He, and E. Jabbari, Biomacromolecules, 8-2, 406-415 (2007).
  • "Synthesis and Characterization of Bioresorbable in situ Crosslinkable Ultra Low Molecular Weight Poly(lactide) Macromer," E. Jabbari and X. He, J. Mater. Sci. Mater. Med., in Press (2007).
  • "Synthesis and material properties of functionalized lactide oligomers as in situ crosslinkable scaffolds for tissue regeneration," E. Jabbari and X. He, Polym. Prepr., 47-2, 353-354 (2006).
  • "Synthesis of novel multi-functional matrix metalloproteinases degradable peptide crosslinkers", E. Jabbari and X. He, Polym. Prepr., 47-2, 192-193 (2006).
  • "Fabrication and Characterization of Poly(Propylene Fumarate) Scaffolds with Controlled Pore Structures Using 3-Dimensional Printing and Injection Molding", K.W. Lee, S. Wang, L. Lu, E. Jabbari, B.L. Currier, and M.J. Yaszemski, Tissue Eng., ahead of print, PMID:17007572 (2006).
  • "Monte Carlo simulation of degradation of porous poly(lactide) scaffolds I. Effect of porosity on pH", Y. Mohammadi and E. Jabbari, Macromol. Theory Simul., in Press (2006).
  • "Effect of surface polarity on wettability and friction coefficient of silicone rubber/ poly(acrylic acid) hydrogel composite", S. Kheirandish and E. Jabbari, Colloid Polym. Sci., 284, 1513-1518 (2006).
  • "Solid-phase synthesis of reactive peptide crosslinker by selective deprotection", X. He and E. Jabbari, Protein & Peptide Lett., 13, 715-718 (2006).
  • "Modeling and Experimental Investigation of Rheological Properties of Injectable Poly(lactide ethylene oxide fumarate)/Hydroxyapatite NanoComposites", A. Sarvestani and E. Jabbari, Biomacromoelcules, 7, 1573-1580 (2006).
  • "Biomimetic Hydrogel/Apatite Nanocomposite Scaffolds for Bone Regeneration, E. Jabbari, Mater. Res. Soc. Symp. Proc., 897E, J07-03.1-03.6 (2006).
Swearingen Engineering Center • Columbia, SC 29208 • 803.777.4177 • webmaster@engr.sc.edu